--- title: update-using-deep-learning-to-discover-functional-antibodies-for-sars-cov-2-with-picomolar-binding-affinity description: "AET 2022: Using deep learning to discover functional antibodies for SARS-CoV-2 with picomolar binding affinity" --- [![ordaos](https://ordaos.bio/hs-fs/hubfs/Ordaos_April2025/images/image.webp?width=140&height=32&name=image.webp "ordaos")](https://ordaos.bio?hsLang=en) - [News](https://ordaos.bio/press) - [Events](https://ordaos.bio/events) - [Team](https://ordaos.bio/team) - [Contact Us](https://ordaos.bio/contact-us) ## AET 2022: Using deep learning to discover functional antibodies for SARS-CoV-2 with picomolar binding affinity After presenting at AET 2022 with updated in vitro results we share this exciting data. Therapeutic SARS-CoV-2 antibody is desired to target S1 whilst addressing its viral evolution and escape mutations. A deep learning-based approach was developed to create, optimize, and rank mini-protein binders for drug-like properties including binding affinity and developability. The approach was used to discover single domain VHH antibodies that bind to S1 Ancestral, Delta and Omicron simultaneously with picomolar to sub-nanomolar affinity and block S1 interaction with human ACE2 in vitro. ![AET 2022: Using deep learning to discover functional antibodies for SARS-CoV-2 with picomolar binding affinity](https://ordaos.bio/hs-fs/hubfs/image%20-aet.webp?width=1920&height=1204&name=image%20-aet.webp "AET 2022: Using deep learning to discover functional antibodies for SARS-CoV-2 with picomolar binding affinity") [![Ordaos](https://ordaos.bio/hubfs/Ordaos_April2025/images/footer-logo.svg "Ordaos")](https://ordaos.bio?hsLang=en) - [News](https://ordaos.bio/press) - [Team](https://ordaos.bio/team) - [Contact Us](https://ordaos.bio/contact-us) - [Careers](https://ordaos.bio/team) #### Connect #### Partner - [Contact Us](https://ordaos.bio/contact-us?hsLang=en) #### Join [Careers](https://ordaos.bio/team/#careers) 228 Park Ave S 60684, New York, NY 10003, USA [Privacy Policy](https://ordaos.bio/privacy-policy?hsLang=en) | [Terms of Use](https://ordaos.bio/terms-of-use?hsLang=en)